Welsh Contributor Welsh, James M. Raw, Laurence Welsh, James M. How could we teach it? Subject Film adaptations -- Authorship Motion picture authorship -- Study and teaching. Library Locations Map Details. Ladd Library Borrow it. Library Links. About Library Policies Services. Embed Experimental. Layout options: Carousel Grid List Card.
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Dennis Cutchins is associate professor of English at Brigham Young University, where he teaches adaptation studies, as well as American and western literature . Get this from a library! Redefining adaptation studies. [Dennis R Cutchins; Laurence Raw; James Michael Welsh;].
Structured data from the Bibframe namespace is licensed under the Creative Commons Attribution 4. Additional terms may apply to data associated with third party namespaces. Link Analysis Experimental. Do they evolve through a series of small beneficial steps as envisioned by Charles Darwin, or through a series of rare but large jumps?
Or through a combination of both? For example, "did a giraffe 's neck get longer because there were thousands of mutations each resulting in a millimeter increase? Marx's research focuses on adaptation, the process by which populations improve in their ability to grow and survive. Understanding how adaptation works in smaller populations is important because many scenarios—from new infections to cancer—involve small numbers of cells.
Until recently, many scientists held the classic Darwinian view that adaptation occurs gradually through a series of small changes, he says. Furthermore, they believed that it is extremely rare that a random mutation would actually benefit an organism in a given environment, he says.
It would also mean that the mutations that won—rising to percent of the population—would give a fairly clear picture of what is biologically possible for that organism. In order to study adaptation, including how organisms can improve, Marx's laboratory grows hundreds of bacterial populations in the laboratory. Scientists can preserve live bacteria in an ultra-cold freezer, allowing them to revive and directly study their common ancestor, the one they used to initiate succeeding generations over time.
Recent work from a number of laboratories, including Marx's, has shown that beneficial mutations actually can occur much more readily than previously thought. He compares this competition between rival genetic innovations to what happens in a market economy when, for example, a new field opens and "many companies enter the race and, over time, the better ones beat out the weaker ones," he says.
Thus, the current theory is that small populations improve via little steps and big populations take big steps.
Advanced Search Help. You are not authenticated to view the full text of this chapter or article. It is thus important to understand the paleoenvironment of this period. Honoring yourself in more varied and creative ways contributes far more to your ultimate success. Here's an example of what they look like: Your reading intentions are also stored in your profile for future reference. A longstanding tenet in the medical literature is that the development of insulin resistance and other features of metabolic syndrome is a pathophysiological process, meaning that it is either caused by a disease or represents a dysregulation of normal physiological mechanisms 8 , We propose that the metabolic syndrome be changed to fat storage condition to more clearly align with its etiology.
The award supports junior faculty who exemplify the role of teacher-scholars through outstanding research, excellent education and the integration of education and research within the context of the mission of their organization. The educational component of his grant includes a project-based lab course built around experimental evolution, and a website where scientists who work in microbial evolution can freely share educational materials.
Specifically, Marx has been studying Methylobacterium, a common microbe that lives on the surface of leaves and eats such things as methanol. Based upon ongoing work evolving Methylobacterium in the laboratory, Marx and his graduate student, Nigel Delaney, have both confirmed and begun to question current beliefs. The second is that big populations should have more infighting than little populations, which is also true.
The third is that big populations will move by big steps, and small populations will move by small steps. Their work is ongoing; however, their current data suggest that the third point might not necessarily be true. We've seen that in our bug, and it completely changes the picture.
The experiments conducted by Marx and others using populations of microbes in the laboratory that they can control allows them to learn about the range of adaptation possibilities in a way that is difficult when directly studying infectious diseases or cancer, where there will be confounding differences in environments, starting strains or host genetics, and medical treatments.
Marx's lab also has begun to examine the outcome of combining more than one beneficial mutation. Last year, in a paper his team published in the journal Science , they reported on a general trend of diminishing returns.
Similarly, a University of Houston group led by Marx's friend and colleague, Tim Cooper, an assistant professor of biology, found this identical trend in the evolution of Escherichia coli. Indeed, later papers with viruses and yeast have seen the same. Ultimately, Marx and Cooper decided to submit their papers at the same time, because "unlike the mutations we studied, we felt our work was more valuable when combined.
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